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A 2025 review article describes how compounds in wasabi, especially 6-MSITC (a type of isothiocyanate), may offer cardiovascular protection by improving endothelial function through pathways like Nrf2/HO-1.
The authors propose that wasabi’s active compounds could mitigate oxidative stress, inflammation, and endothelial dysfunction — all factors implicated in heart disease. ScienceDirect
A 2022 animal study showed that wasabi extract attenuated inflammatory cell infiltration in the cardiac tissue of obese rats. PMC
The study suggests that the isothiocyanates in wasabi may help reduce cardiac inflammation under metabolic stress. PMC